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Article

Computational pan-genome mapping and pairwise SNP-distance improve detection of Mycobacterium tuberculosis transmission clusters.

PLoS computational biology - 1 Dec 2019

Jandrasits Christine, Kröger Stefan, Haas Walter, Renard Bernhard Y

Abstract excerpt

Next-generation sequencing based base-by-base distance measures have become an integral complement to epidemiological investigation of infectious disease outbreaks. This study introduces PANPASCO, a computational pan-genome mapping based, pairwise distance method that is highly sensitive to differences between cases, even when located in regions of lineage specific reference genomes. We show that our approach is...

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Identifiers

PMID: 31815935
DOI: 10.1371/journal.pcbi.1007527
PMCID: PMC6922483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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