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Pan- and core genome analysis of Mycobacterium tuberculosis in high-resolution transmission and genetic diversity studies.

Microbial genomics - 1 Oct 2025

Liu Zhengwei, Pei Shaojun, Ou Xichao, Li Xiangchen, Zhu Yelei, Lu Yewei, Zhang Mingwu, Che Yang, Wu Kunyang, Wang Xiaomeng, Zhao Yanlin

Abstract excerpt

The application of pan-genomics in understanding Mycobacterium tuberculosis complex (MTBC) transmission remains understudied, particularly in high-burden settings such as China. We constructed an M. tuberculosis complex pan-genome (MTB_pan) using 307 complete genomes representing all eight lineages from the National Center for Biotechnology Information (NCBI). Core and accessory genomes were analysed,...

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PMID: 41042591
DOI: 10.1099/mgen.0.001460

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