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Article

Redefinition of transmission clusters by accessing to additional diversity in Mycobacterium tuberculosis through long-read sequencing.

Pathogens and global health - 1 Dec 2025

Buenestado-Serrano Sergio, Vallejo-Godoy Silvia, Escabias Machuca Francisca, Barroso Pilar, Martínez-Lirola Miguel, Cabezas Teresa, Muñoz Patricia, Pérez-Lago Laura, García de Viedma Darío

Abstract excerpt

Whole-genome sequencing, supported on short-read-sequencing, has revolutionized the precision to track Mycobacterium tuberculosis (MTB) transmission. However, the complexity of the MTB genome (10% repetitive regions and 65% GC content) challenges short-read mapping and assembly, leading to the exclusion of certain genomic regions from the analysis. Long-read sequencing can overcome these limitations, giving...

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Topics

Mycobacterium tuberculosis
Humans
Spain
Tuberculosis
Whole Genome Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Cluster Analysis

Genetic Variation

Molecular Epidemiology

Genome, Bacterial

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 40986624
DOI: 10.1080/20477724.2025.2555926
PMCID: PMC12642902

Genes

GC

Provenance

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