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Computational Pan-genome Mapping and pairwise SNP-distance improve Detection of <i>Mycobacterium tuberculosis</i> Transmission Clusters

2019-09-02

Abstract excerpt

Next-generation sequencing based base-by-base distance measures have become an integral complement to epidemiological investigation of infectious disease outbreaks. This study introduces PANPASCO, a computational pan-genome mapping based, pairwise distance method that is highly sensitive to differences between cases, even when located in regions of lineage specific reference genomes. We show that our approach is s...

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Literature Corpus work
ec351296-07ee-5f11-879b-ed8dfdd05af5
DOI
10.1101/752782
Open publication

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Computational Pan-genome Mapping and pairwise SNP-distance improve Detection of <i>Mycobacterium tuberculosis</i> Transmission ClustersDOI 10.1101/752782
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