Article
Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.
PloS one - 1 Jan 2018
Jajou Rana, de Neeling Albert, van Hunen Rianne, de Vries Gerard, Schimmel Henrieke, Mulder Arnout, Anthony Richard, van der Hoek Wim, van Soolingen Dick
Abstract excerpt
BACKGROUND: Patients with Mycobacterium tuberculosis isolates sharing identical DNA fingerprint patterns can be epidemiologically linked. However, municipal health services in the Netherlands are able to confirm an epidemiological link in only around 23% of the patients with isolates clustered by the conventional variable number of tandem repeat (VNTR) genotyping. This research aims to investigate whether whole...
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