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Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

8 Dec 2019

Abstract excerpt

Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression rate. CD8+ T cells have been implicated in the autoimmune destruction of β cells. Here, we addressed whether the phenotype and function of autoreactive CD8+ T cells...

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PMID: 31815738
DOI: 10.1172/jci126595

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