Article
Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome.
eLife - 9 Dec 2019
Morgenthaler Andrew B, Kinney Wallis R, Ebmeier Christopher C, Walsh Corinne M, Snyder Daniel J, Cooper Vaughn S, Old William M, Copley Shelley D
Abstract excerpt
New enzymes often evolve by gene amplification and divergence. Previous experimental studies have followed the evolutionary trajectory of an amplified gene, but have not considered mutations elsewhere in the genome when fitness is limited by an evolving gene. We have evolved a strain of Escherichia coli in which a secondary promiscuous activity has been recruited to serve an essential function. The gene encoding...
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