Enzyme recruitment and its role in metabolic expansion.

Abstract excerpt

Although more than 10(9) years have passed since the existence of the last universal common ancestor, proteins have yet to reach the limits of divergence. As a result, metabolic complexity is ever expanding. Identifying and understanding the mechanisms that drive and limit the divergence of protein sequence space impact not only evolutionary biologists investigating molecular evolution but also synthetic...

Topics

• Animals
• Biocatalysis
• Directed Molecular Evolution
• Enzymes
• Epistasis, Genetic
• Evolution, Molecular
• Humans
• Metabolic Networks and Pathways
• Mutation
• Phylogeny
• Synthetic Biology