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Article

How to Recruit a Promiscuous Enzyme to Serve a New Function.

Biochemistry - 17 Jan 2023

Copley Shelley D, Newton Matilda S, Widney Karl A

Abstract excerpt

Promiscuous enzymes can be recruited to serve new functions when a genetic or environmental change makes catalysis of a novel reaction important for fitness or even survival. Subsequently, gene duplication and divergence can lead to evolution of an efficient and specialized new enzyme. Every organism likely has thousands of promiscuous enzyme activities that provide a vast reservoir of catalytic potential....

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Identifiers

PMID: 35729117
DOI: 10.1021/acs.biochem.2c00249
PMCID: PMC9881647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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