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Article

Random sequences rapidly evolve into de novo promoters.

Nature communications - 18 Apr 2018

Yona Avihu H, Alm Eric J, Gore Jeff

Abstract excerpt

How new functions arise de novo is a fundamental question in evolution. We studied de novo evolution of promoters in Escherichia coli by replacing the lac promoter with various random sequences of the same size (~100 bp) and evolving the cells in the presence of lactose. We find that ~60% of random sequences can evolve expression comparable to the wild-type with only one mutation, and that ~10% of random...

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Identifiers

PMID: 29670097
DOI: 10.1038/s41467-018-04026-w
PMCID: PMC5906472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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