Article
Bacterial adaptation through loss of function.
PLoS genetics - 1 Jan 2013
Hottes Alison K, Freddolino Peter L, Khare Anupama, Donnell Zachary N, Liu Julia C, Tavazoie Saeed
Abstract excerpt
The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the same bacteria may grow poorly due to regulatory constraints or biochemical deficiencies. Adaptation to such conditions can proceed through the acquisition of new cellular functionality due to gain of...
Topics
- Adaptation, Physiological
- Bacteria
- DNA Transposable Elements
- Directed Molecular Evolution
- Environment
- Food
- Mutation
- Selection, Genetic