Article
Network-level architecture and the evolutionary potential of underground metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2014
Notebaart Richard A, Szappanos Balázs, Kintses Bálint, Pál Ferenc, Györkei Ádám, Bogos Balázs, Lázár Viktória, Spohn Réka, Csörgő Bálint, Wagner Allon, Ruppin Eytan, Pál Csaba, Papp Balázs
Abstract excerpt
A central unresolved issue in evolutionary biology is how metabolic innovations emerge. Low-level enzymatic side activities are frequent and can potentially be recruited for new biochemical functions. However, the role of such underground reactions in adaptation toward novel environments has remained largely unknown and out of reach of computational predictions, not least because these issues demand analyses at...
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