Article
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph.
Nature communications - 6 Dec 2019
van de Sandt C E, Clemens E B, Grant E J, Rowntree L C, Sant S, Halim H, Crowe J, Cheng A C, Kotsimbos T C, Richards M, Miller A, Tong S Y C, Rossjohn J, Nguyen T H O, Gras S, Chen W, Kedzierska K
Abstract excerpt
Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8+ T cells to mount robust responses. We elucidate the HLA-A*68:01+CD8+ T cell response directed toward an extended...
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