Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.

doi:10.1126/sciimmunol.abk3070

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.

Science immunology - 21 Jan 2022

Francis Joshua M, Leistritz-Edwards Del, Dunn Augustine, Tarr Christina, Lehman Jesse, Dempsey Conor, Hamel Andrew, Rayon Violeta, Liu Gang, Wang Yuntong, Wille Marcos, Durkin Melissa, Hadley Kane, Sheena Aswathy, Roscoe Benjamin, Ng Mark, Rockwell Graham, Manto Margaret, Gienger Elizabeth, Nickerson Joshua, Moarefi Amir, Noble Michael, Malia Thomas, Bardwell Philip D, Gordon William, Swain Joanna, Skoberne Mojca, Sauer Karsten, Harris Tim, Goldrath Ananda W, Shalek Alex K, Coyle Anthony J, Benoist Christophe, Pregibon Daniel C

Abstract excerpt

Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cells is required for viral elimination and generation of long-term immunological memory. In this study, we applied a single-cell, multiomic technology to generate a unified ex vivo characterization of the CD8+ T cell response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across four major HLA class I...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to COVID-19

Share to Histocompatibility Antigens Class I

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to SARS-CoV-2

Share to SARS-CoV-2 and COVID-19 Research

Share to vaccines and immunoinformatics approaches

Source

Open in PubMed Open full text

Identifiers

PMID: 34793243
DOI: 10.1126/sciimmunol.abk3070
PMCID: PMC9017864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.PMID 34793243Read ↗

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8 + T cell repertoire upon viral exposureSemantic proximity Read ↗

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 + T-cells reveal strong functional impairment and recognition bias as markers for disease severitySemantic proximity Read ↗

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read ↗

Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level.Semantic proximity Read ↗

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infectionSemantic proximity Read ↗

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 eraSemantic proximity Read ↗

Distinct CD8 + T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 + PatientsSemantic proximity Read ↗

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.Semantic proximity Read ↗

Leveraging T-cell receptor – epitope recognition models to disentangle unique and cross-reactive T-cell response to SARS-CoV-2 during COVID-19 progression/resolutionSemantic proximity Read ↗

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infectionSemantic proximity Read ↗

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.Semantic proximity Read ↗

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.