Article

Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotype

2020-08-19

Abstract excerpt

An improved understanding of human T-cell-mediated immunity in COVID-19 is important if we are to optimize therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8 + T-cell memory to shared peptides presented by common HLA types like HLA-A2. Following re-infection, cross-reactive CD8 + T-cells enhance recovery and diminish clinical severity. Stimulating peripheral blood mononuc...

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Literature Corpus work: b8f6b04a-6d64-50ec-9887-066c7fc377f6
DOI: 10.1101/2020.08.17.20176370

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