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Article

Molecular basis for universal HLA-A*0201–restricted CD8 <sup>+</sup> T-cell immunity against influenza viruses

31 Mar 2016

Abstract excerpt

Memory CD8(+)T lymphocytes (CTLs) specific for antigenic peptides derived from internal viral proteins confer broad protection against distinct strains of influenza A virus (IAV). However, immune efficacy can be undermined by the emergence of escape mutants. To determine how T-cell receptor (TCR) composition relates to IAV epitope variability, we used ex vivo peptide-HLA tetramer enrichment and single-cell...

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PMID: 27036003
DOI: 10.1073/pnas.1603106113

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