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CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age

29 Apr 2024

Abstract excerpt

Abstract Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8 + T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is...

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PMID: 38684663
DOI: 10.1038/s41467-024-47576-y

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