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Article

Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adults

17 Apr 2025

Abstract excerpt

Background Susceptibility to life-threatening influenza increases with age, partly due to declining immunity. Frequency, phenotype and T-cell receptor (TCR) composition of influenza-specific CD8 + T-cells directed at the prominent A2/M1 58 influenza epitope change across the human lifespan. Methods We investigated longevity and mechanisms underlying age-related changes in influenza-specific TCR repertoires by...

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Identifiers

PMID: 40250246
DOI: 10.1016/j.ebiom.2025.105697

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