Fine mapping of the MHC region identifies major independent variants associated with Han Chinese primary biliary cholangitis.

doi:10.1016/j.jaut.2019.102372

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Article

Fine mapping of the MHC region identifies major independent variants associated with Han Chinese primary biliary cholangitis.

Journal of autoimmunity - 1 Feb 2020

Wang Chan, Zheng Xiaodong, Tang Ruqi, Han Chongxu, Jiang Yuzhang, Wu Jian, Shao Youlin, Gao Yueqiu, Yu Jianjiang, Hu Zhigang, Zang Zhidong, Zhao Yi, Dai Na, Liu Lei, Wu Xudong, Nie Jinshan, Jiang Bo, Lin Maosong, Li Li, Wei Yiran, Li You, Gong Yuhua, Dai Yaping, Wang Lan, Ding Ningling, Xu Ping, Chen Sufang, Jiang Peng, Wang Lu, Qiu Fang, Wu Qiuyuan, Zhang Mingming, Jawed Rohil, Chen Ru, Zhang Yu, Shi Xingjuan, Zhu Zhen, Pei Hao, Huang Lihua, Tian Ye, Zhang Kui, Qiu Hong, Zhao Weifeng, Gershwin M Eric, Chen Weichang, Seldin Michael F, Liu Xiangdong, Ma Xiong, Sun Liangdan

Abstract excerpt

The genetic association of primary biliary cholangitis with major histocompatibility complex (MHC) has been widely confirmed among different ethnicities. To map specific MHC region variants associated with PBC in a Han Chinese cohort, we imputed HLA antigens and amino acids (AA) in 1126 PBC cases and 1770 healthy control subjects using a Han-MHC reference database. We demonstrate that HLA-DRB1 and/or HLA-DQB1...

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PMID: 31810856
DOI: 10.1016/j.jaut.2019.102372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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