Article
HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study.
Hepatology (Baltimore, Md.) - 1 Sept 2006
Donaldson Peter T, Baragiotta Anna, Heneghan Michael A, Floreani Annarosa, Venturi Carla, Underhill James A, Jones David E J, James Oliver F W, Bassendine Margaret F
Abstract excerpt
Twin and family studies suggest there is a significant genetic component to primary biliary cirrhosis (PBC). However, the inability to replicate reported associations has been a recurring problem, with the only consistently reported genetic association that between PBC and HLA-DRB1*0801. However, recently even this has been questioned, and a number of novel associations have also been reported. We reinvestigated...
Topics
- Alleles
- Amino Acids
- DNA
- Disease Progression
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes