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Article

New insights on the role of human leukocyte antigen complex in primary biliary cholangitis.

Frontiers in immunology - 1 Jan 2022

Mulinacci Giacomo, Palermo Andrea, Gerussi Alessio, Asselta Rosanna, Gershwin Merrill Eric, Invernizzi Pietro

Abstract excerpt

Primary Biliary Cholangitis (PBC) is a rare autoimmune cholangiopathy. Genetic studies have shown that the strongest statistical association with PBC has been mapped in the human leukocyte antigen (HLA) locus, a highly polymorphic area that mostly contribute to the genetic variance of the disease. Furthermore, PBC presents high variability throughout different population groups, which may explain the different...

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Identifiers

PMID: 36119102
DOI: 10.3389/fimmu.2022.975115
PMCID: PMC9471323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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