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Article

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.

European journal of immunology - 1 Apr 2020

Valta Milla, Gazali Ahmad Mahfuz, Viisanen Tyyne, Ihantola Emmi-Leena, Ekman Ilse, Toppari Jorma, Knip Mikael, Veijola Riitta, Ilonen Jorma, Lempainen Johanna, Kinnunen Tuure

Abstract excerpt

Dysfunction of FOXP3-positive regulatory T cells (Tregs) likely plays a major role in the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). Whether genetic polymorphisms associated with the risk of autoimmune diseases affect Treg frequency or function is currently unclear. Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide...

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Identifiers

PMID: 31808541
DOI: 10.1002/eji.201948378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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