Article
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Frontiers in immunology - 1 Jan 2019
Ferreira Ricardo C, Castro Dopico Xaquin, Oliveira João J, Rainbow Daniel B, Yang Jennie H, Trzupek Dominik, Todd Sarah A, McNeill Mhairi, Steri Maristella, Orrù Valeria, Fiorillo Edoardo, Crouch Daniel J M, Pekalski Marcin L, Cucca Francesco, Tree Tim I, Vyse Tim J, Wicker Linda S, Todd John A
Abstract excerpt
In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4+ T-cell activity. However, to date, the characterization of the CD4+ regulatory T cell (Treg) compartment in SLE has yielded conflicting results. Here we show that patients have an increased frequency of CD4+FOXP3+ cells in circulation owing to a specific expansion of...
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