Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls.

Autoimmunity - 1 Dec 2023

Pahkuri Sirpa, Ekman Ilse, Vandamme Céline, Näntö-Salonen Kirsti, Toppari Jorma, Veijola Riitta, Knip Mikael, Kinnunen Tuure, Ilonen Jorma, Lempainen Johanna

Abstract excerpt

We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte subsets using pyrosequencing. The study cohort comprised 25 children with newly diagnosed T1D and 25 matched healthy controls. The rs689...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Child
Share to Diabetes Mellitus, Type 1
Share to DNA Methylation
Share to Genotype
Share to Interleukin-2 Receptor alpha Subunit
Share to Lymphocyte Subsets
Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 37724526
DOI: 10.1080/08916934.2023.2259118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls.PMID 37724526Read ↗

CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.Semantic proximity Read ↗

DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.Semantic proximity Read ↗

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.Semantic proximity Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Early DNA methylation changes in children developing beta cell autoimmunity at a young ageSemantic proximity Read ↗

The effect of type 1 diabetes protection and susceptibility associated HLA class II genotypes on DNA methylation in immune cells.Semantic proximity Read ↗

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.Semantic proximity Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?Semantic proximity Read ↗

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 DiabetesSemantic proximity Read ↗

No association between IRS‑1 promoter methylation and type 2 diabetes.Semantic proximity Read ↗

Longitudinal DNA methylation differences precede type 1 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.