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Article

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells.

Genes and immunity - 1 Jan 2017

Marwaha A K, Panagiotopoulos C, Biggs C M, Staiger S, Del Bel K L, Hirschfeld A F, Priatel J J, Turvey S E, Tan R

Abstract excerpt

T-regulatory cells (Tregs) are essential for immune tolerance, and animal studies implicate their dysfunction in type 1 diabetes (T1D) pathogenesis. Tregs require interleukin-2 (IL-2) for their suppressive function, and variants in IL-2/IL-2R pathway genes have been associated with T1D. We previously reported that recent-onset T1D subjects have an increased population of FOXP3lo Tregs that secrete the...

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Identifiers

PMID: 28053319
DOI: 10.1038/gene.2016.44
PMCID: PMC5843473

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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