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Article

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes.

Diabetes - 1 Nov 2015

Yang Jennie H M, Cutler Antony J, Ferreira Ricardo C, Reading James L, Cooper Nicholas J, Wallace Chris, Clarke Pamela, Smyth Deborah J, Boyce Christopher S, Gao Guo-Jian, Todd John A, Wicker Linda S, Tree Timothy I M

Abstract excerpt

Defective immune homeostasis in the balance between FOXP3+ regulatory T cells (Tregs) and effector T cells is a likely contributing factor in the loss of self-tolerance observed in type 1 diabetes (T1D). Given the importance of interleukin-2 (IL-2) signaling in the generation and function of Tregs, observations that polymorphisms in genes in the IL-2 pathway associate with T1D and that some individuals with T1D...

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Share to Diabetes Mellitus, Type 1
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Interleukin-2 Receptor alpha Subunit

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 26224887
DOI: 10.2337/db15-0516
PMCID: PMC4975524

Genes

FOXP3
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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