Article
Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies.
Scientific reports - 30 Nov 2022
Pouw Juliëtte N, Olde Nordkamp Michel A M, van Kempen Tessa, Concepcion Arno N, van Laar Jacob M, van Wijk Femke, Spierings Julia, Leijten Emmerik F A, Boes Marianne
Abstract excerpt
In psoriatic arthritis (PsA), predisposing class I HLA alleles, the presence of synovial clonally proliferated CD8 + T cells and autoantibodies all point towards the loss of immune tolerance. However, the key mechanisms that lead to immune dysregulation are not fully understood. In other types of inflammatory arthritis, T regulatory cell (Treg) dysfunction and plasticity at sites of inflammation were suggested to...
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