Article
Flexible and Extended Linker Domains Support Efficient Targeting of Heh2 to the Inner Nuclear Membrane.
Structure (London, England : 1993) - 4 Feb 2020
Rempel Irina L, Popken Petra, Ghavami Ali, Mishra Ankur, Hapsari Rizqiya A, Wolters Anouk H G, Veldsink Annemiek C, Klaassens Marindy, Meinema Anne C, Poolman Bert, Giepmans Ben N G, Onck Patrick R, Steen Anton, Veenhoff Liesbeth M
Abstract excerpt
The nuclear pore complex (NPC) is embedded in the nuclear envelope and forms the main gateway to the nuclear interior including the inner nuclear membrane (INM). Two INM proteins in yeast are selectively imported. Their sorting signals consist of a nuclear localization signal, separated from the transmembrane domain by a long intrinsically disordered (ID) linker. We used computational models to predict the...
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