Article
Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.
Nature communications - 10 Sept 2018
Schütz Sabina, Michel Erich, Damberger Fred F, Oplová Michaela, Peña Cohue, Leitner Alexander, Aebersold Ruedi, Allain Frederic H-T, Panse Vikram Govind
Abstract excerpt
Disordered extensions at the termini and short internal insertions distinguish eukaryotic ribosomal proteins (r-proteins) from their anucleated archaeal counterparts. Here, we report an NMR structure of such a eukaryotic-specific segment (ESS) in the r-protein eS26 in complex with the escortin Tsr2. The structure reveals how ESS attracts Tsr2 specifically to importin:eS26 complexes entering the nucleus in order...
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