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Article

Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.

Biochemistry - 21 Sept 2010

Kondé Emilie, Bourgeois Benjamin, Tellier-Lebegue Carine, Wu Wei, Pérez Javier, Caputo Sandrine, Attanda Wika, Gasparini Sylvaine, Charbonnier Jean-Baptiste, Gilquin Bernard, Worman Howard J, Zinn-Justin Sophie

Abstract excerpt

MAN1, an integral protein of the inner nuclear membrane, influences transforming growth factor-β (TGF-β) signaling by directly interacting with R-Smads. Heterozygous loss of function mutations in the gene encoding MAN1 cause sclerosing bone dysplasias and an increased level of TGF-β signaling in...

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PMID: 20715792
DOI: 10.1021/bi101153w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20715792-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.PMID 20715792Read ↗

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