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Article

Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.

Cell - 6 Apr 2007

Patel Samir S, Belmont Brian J, Sante Joshua M, Rexach Michael F

Abstract excerpt

Nuclear pore complexes (NPCs) form aqueous conduits in the nuclear envelope and gate the diffusion of large proteins between the cytoplasm and nucleoplasm. NPC proteins (nucleoporins) that contain phenylalanine-glycine motifs in filamentous, natively unfolded domains (FG domains) line the diffusion conduit of the NPC, but their role in the size-selective barrier is unclear. We show that deletion of individual FG...

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Identifiers

PMID: 17418788
DOI: 10.1016/j.cell.2007.01.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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