Article
A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
The Journal of biological chemistry - 26 Mar 2010
Bhattacharya Shibani, Dai Zhongping, Li Jianquan, Baxter Sabine, Callaway David J E, Cowburn David, Bu Zimei
Abstract excerpt
The mammalian Na(+)/H(+) exchange regulatory factor 1 (NHERF1) is a multidomain scaffolding protein essential for regulating the intracellular trafficking and macromolecular assembly of transmembrane ion channels and receptors. NHERF1 consists of tandem PDZ-1, PDZ-2 domains that interact with the cytoplasmic domains of membrane proteins and a C-terminal (CT) domain that binds the membrane-cytoskeleton linker...
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