Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation on the CRH Gene Determines the Different Performance of Opioid Addicts and Healthy Controls in the IOWA Gambling Task.

Neuropsychobiology - 1 Jan 2020

Seeliger Christian, Lippold Julia V, Reuter Martin

Abstract excerpt

BACKGROUND: The hypothalamus-pituitary-adrenal (HPA) axis, the biological substrate of stress reactivity, and related genetic variations play a crucial role in the initiation and maintenance of drug addiction. On the behavioral level, substance abusers are characterized by impulsivity and the inability to pursue long-term goals. The neural substrate of these behaviors is assumed to be related to the ventromedial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Corticotropin-Releasing Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Decision Making

Share to Haplotypes

Share to Hypothalamo-Hypophyseal System

Share to Opioid-Related Disorders

Share to Polymorphism, Single Nucleotide

Share to Young Adult

Source

Identifiers

PMID: 31805553
DOI: 10.1159/000504227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation on the CRH Gene Determines the Different Performance of Opioid Addicts and Healthy Controls in the IOWA Gambling Task.PMID 31805553Read ↗

Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence.Semantic proximity Read ↗

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.Semantic proximity Read ↗

Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.Semantic proximity Read ↗

HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.Semantic proximity Read ↗

Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.Semantic proximity Read ↗

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA.Semantic proximity Read ↗

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.Semantic proximity Read ↗

Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity.Semantic proximity Read ↗

A Preliminary Study of DBH (Encoding Dopamine Beta-Hydroxylase) Genetic Variation and Neural Correlates of Emotional and Motivational Processing in Individuals With and Without Pathological Gambling.Semantic proximity Read ↗

Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.Semantic proximity Read ↗

Serotonergic modulation of 'waiting impulsivity' is mediated by the impulsivity phenotype in humans.Semantic proximity Read ↗

Drug addiction and stress-response genetic variability: association study in African Americans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.