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Article

HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.

Journal of psychiatric research - 1 Feb 2013

Guillaume Sebastien, Perroud Nader, Jollant Fabrice, Jaussent Isabelle, Olié Emilie, Malafosse Alain, Courtet Philippe

Abstract excerpt

Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23177644
DOI: 10.1016/j.jpsychires.2012.10.014

Genes

CRHR1
CRHR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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