Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA.

Molecular psychiatry - 1 May 2007

Jabbi M, Korf J, Kema I P, Hartman C, van der Pompe G, Minderaa R B, Ormel J, den Boer J A

Abstract excerpt

Highly prevalent stress-related disorders such as major depression (MD) are characterised by a dysregulation of the neuroendocrine system. Although heritability for these disorders is high, the role of genes in the underlying pathophysiology is poorly understood. Here, we show that polymorphic va...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenocorticotropic Hormone
Share to Catechol O-Methyltransferase
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Hypothalamo-Hypophyseal System

Share to Monoamine Oxidase

Share to Pituitary-Adrenal System

Share to Stress, Psychological

Source

Identifiers

PMID: 17453062
DOI: 10.1038/sj.mp.4001975

Genes

MAOA
COMT
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17453062-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA.PMID 17453062Read ↗

Genetically based reduced MAOA and COMT functioning is associated with the cortisol stress response: a replication studySemantic proximity Read ↗

Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response.Semantic proximity Read ↗

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.Semantic proximity Read ↗

Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery.Semantic proximity Read ↗

Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.Semantic proximity Read ↗

Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression.Semantic proximity Read ↗

Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.Semantic proximity Read ↗

The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.Semantic proximity Read ↗

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

Catecholamines and aggression: the role of COMT and MAO polymorphisms.Semantic proximity Read ↗

The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.