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Article

Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2014

Anastasio Noelle C, Stutz Sonja J, Fox Robert G, Sears Robert M, Emeson Ronald B, DiLeone Ralph J, O'Neil Richard T, Fink Latham H, Li Dingge, Green Thomas A, Moeller F Gerard, Cunningham Kathryn A

Abstract excerpt

Relapse vulnerability in cocaine dependence is rooted in genetic and environmental determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues ('cue reactivity'). The serotonin (5-hydroxytryptamine, 5-HT) 5-HT2C receptor (5-HT2CR) within the medial prefrontal cortex (mPFC) is uniquely poised to serve as a strategic nexus to mechanistically control these behaviors. The 5-HT2CR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Serotonin, 5-HT2C

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Identifiers

PMID: 23939424
DOI: 10.1038/npp.2013.199
PMCID: PMC3970795

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