Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.

eLife - 5 Dec 2019

Manatschal Cristina, Pujol-Giménez Jonai, Poirier Marion, Reymond Jean-Louis, Hediger Matthias A, Dutzler Raimund

Abstract excerpt

In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition could be beneficial for the treatment of iron overload disorders. Here we characterize the interaction of aromatic bis-isothiourea-substituted compounds with human DMT1 and its prokaryotic homologue EcoDMT. Both transporters are inhibited by a common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to HEK293 Cells

Share to Ion Transport

Share to Kinetics

Share to Metals

Share to Models, Molecular

Source

Open in PubMed Open full text

Identifiers

PMID: 31804182
DOI: 10.7554/eLife.51913
PMCID: PMC6917499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.PMID 31804182Read ↗

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety EvaluationSemantic proximity Read ↗

Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.Semantic proximity Read ↗

H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics.Semantic proximity Read ↗

Equilibrative nucleoside transporters-A review.Semantic proximity Read ↗

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporterSemantic proximity Read ↗

Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters.Semantic proximity Read ↗

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneineSemantic proximity Read ↗

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneineSemantic proximity Read ↗

Structures of multidrug and toxic compound extrusion transporters and their mechanistic implicationsSemantic proximity Read ↗

Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3Semantic proximity Read ↗

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.Semantic proximity Read ↗

Metal transporters and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.