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Article

H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics.

Current topics in membranes - 1 Jan 2012

Shawki Ali, Knight Patrick B, Maliken Bryan D, Niespodzany Eric J, Mackenzie Bryan

Abstract excerpt

Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring membrane transport protein. Animal models establish that DMT1 plays indispensable roles in intestinal nonheme-iron absorption and iron acquisition by erythroid precursor cells. Rare mutations in human DMT1 result in severe microcytic-hypochromic anemia. When we express DMT1 in RNA-injected Xenopus oocytes, we observe rheogenic Fe(2+)...

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Identifiers

PMID: 23177986
DOI: 10.1016/B978-0-12-394316-3.00005-3
PMCID: PMC7027397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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