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Article

Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.

Nature communications - 6 Jan 2017

Ehrnstorfer Ines A, Manatschal Cristina, Arnold Fabian M, Laederach Juerg, Dutzler Raimund

Abstract excerpt

Secondary active transporters of the SLC11/NRAMP family catalyse the uptake of iron and manganese into cells. These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. Here we describe the structural and functional properties of the prokaryotic SLC11 transporter EcoDMT. Its crystal structure reveals a previously unknown outward-facing state of the protein...

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Identifiers

PMID: 28059071
DOI: 10.1038/ncomms14033
PMCID: PMC5230734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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