Article

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

2022-09-04

Abstract excerpt

<h4>ABSTRACT</h4> Divalent metal transporter 1 (DMT1) cotransports ferrous iron and protons and is the primary mechanism for uptake of non-heme iron by enterocytes. Inhibitors are potentially useful as therapeutic agents to treat iron overload disorders such as hereditary hemochromatosis or β-thalassemia intermedia, provided that inhibition can be restricted to the duodenum. We used a calcein quench assay to iden...

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Literature Corpus work: 26c14484-ddf3-57ec-a499-39cc9d93ac8f
DOI: 10.1101/2022.09.01.506269

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