Article

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine

2022-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Ergothioneine (ET) is the 2-thiourea derivative of trimethylhistidine that is biosynthesized only by select fungi and bacteria, notably Mycobacterium tuberculosis , and functions as a potent scavenger of reactive oxygen species. Although ET is obtained in the diet and accumulates in vertebrate cells via an ET-specific transporter, the extent to which ET broadly functions in bacterial cells unab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 427352f6-6d5e-543f-8e72-3db5be062d3d
DOI: 10.1101/2022.05.02.490363

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneineDOI 10.1101/2022.05.02.490363Read

Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneineSemantic proximity Read

Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtDSemantic proximity Read

Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis.Semantic proximity Read

Role of Ergothioneine in Microbial Physiology and PathogenesisSemantic proximity Read

Structure of mycobacterial ergothioneine-biosynthesis C-S lyase EgtESemantic proximity Read

The proteobacterial species <i>Burkholderia pseudomallei</i> produces ergothioneine, which enhances virulence in mammalian infectionSemantic proximity Read

Structural basis of ergothioneine biosynthesisSemantic proximity Read

Engineering Mycolicibacterium neoaurum for the production of antioxidant ergothioneineSemantic proximity Read

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.Semantic proximity Read

Prokaryotic ammonium transporters: what has three decades of research revealed?Semantic proximity Read

Structural insights into a conserved mechanism of choline translocation through CHTSemantic proximity Read

Does Lactobacillus reuteri influence ergothioneine levels in the human body?Semantic proximity Read