Article

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

2025-05-13

Abstract excerpt

d -Block metal transporters play a crucial role in maintaining the homeostasis of life-essential trace elements and are attractive targets for protein engineering aimed to selectively enriching or excluding metals in living organisms. However, systematic efforts to engineer these transporters have been hindered by limited understanding of their transport mechanism and substrate specificity. In this study, we appli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e07571c6-280d-5271-9682-55c6a1a83f67
DOI: 10.1101/2025.05.07.652779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporterDOI 10.1101/2025.05.07.652779Read

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.Semantic proximity Read

Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defectsSemantic proximity Read

Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.Semantic proximity Read

Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.Semantic proximity Read

A First-In-Class Broad Spectrum Inhibitor of Copper Exporting P <sub>1B</sub> -type ATPasesSemantic proximity Read

The metal binding site composition of the cation diffusion facilitator protein MamM cytoplasmic domain impacts its metal responsivity.Semantic proximity Read

The two-domain elevator-type mechanism of zinc-transporting ZIP proteinsSemantic proximity Read

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.Semantic proximity Read

Metal Selectivity of a Cd-, Co-, and Zn-Transporting P1B-type ATPase.Semantic proximity Read

Systematic analysis of naturally occurring missense mutations in human manganese transporters: prediction and structural insightsSemantic proximity Read

Metal transporters and diseaseSemantic proximity Read

Symmetry Analysis and Ancestral Sequence Reconstruction Reveal a Symmetrical Translocation Pathway and Activity Determinants of ZIP Metal TransporterSemantic proximity Read