Article
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor.
Molecular medicine (Cambridge, Mass.) - 9 Apr 2024
Fasano Giulia, Petrini Stefania, Bonavolontà Valeria, Paradisi Graziamaria, Pedalino Catia, Tartaglia Marco, Lauri Antonella
Abstract excerpt
BACKGROUND: RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulators of the RAS-MAPK signaling pathway generally leading to an upregulated ERK activity. Gain-of-function (GOF) mutations in PTPN11, encoding SHP2, a cytosolic protein tyrosine phosphatase...
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