Back to search

Article

A transgenic zebrafish for spatiotemporal optogenetic activation of FGF/ERK signaling

2026-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Dynamic FGF/ERK signaling plays key roles in development, regeneration, and disease. We recently developed a zebrafish-optimized optogenetic tool, bOpto-FGF, that enables reversible activation of FGF/ERK signaling in response to blue light (∼455 nm) by fusing a zebrafish receptor tyrosine kinase domain to the blue light-dimerizing LOV domain. Previously, this tool was introduced into zebrafish e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2376a99a-4e1e-5fa5-8b80-01bf0233a625
DOI
10.64898/2026.05.12.724650
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A transgenic zebrafish for spatiotemporal optogenetic activation of FGF/ERK signalingDOI 10.64898/2026.05.12.724650
An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafishSemantic proximity
Optogenetic Signaling Activation in Zebrafish EmbryosSemantic proximity
Optogenetic control of the Bone Morphogenetic Protein signalling pathway through engineered blue light-sensitive receptorsSemantic proximity
Protocol to locally express cxcl12a during zebrafish olfactory organ development by combining IR-LEGO with live imaging.Semantic proximity
Optical Control of Tumor Induction in the Zebrafish.Semantic proximity
FRET imaging of Teen sensor captures ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitorSemantic proximity
Optogenetic manipulation of YAP cellular localisation and functionSemantic proximity
Light reaches the very heart of the zebrafish clock.Semantic proximity
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor.Semantic proximity
Fluorescent imaging of cancer in zebrafish.Semantic proximity
One-step generation of zebrafish carrying a conditional knockout-knockin visible switch via CRISPR/Cas9-mediated intron targeting.Semantic proximity
A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseasesSemantic proximity
Select a neighboring publication to make it the new centre.