Article

FRET imaging of Teen sensor captures ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor

2023-09-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold> RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related, and are caused by germline mutations affecting key players and regulators of the RAS-MAPK signaling pathway generally leading to an upregulated ERK activity. Gain-of-function (GOF) mutations in PTPN11, encoding SHP2, a cytoso...

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Literature Corpus work: 6c4b1e01-48ff-5a96-a333-a0883c0981fc
DOI: 10.21203/rs.3.rs-3356383/v1

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