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Article

Molecular mechanisms underlying cellular effects of human MEK1 mutations.

Molecular biology of the cell - 19 Apr 2021

Marmion Robert A, Yang Liu, Goyal Yogesh, Jindal Granton A, Wetzel Joshua L, Singh Mona, Schüpbach Trudi, Shvartsman Stanislav Y

Abstract excerpt

Terminal regions of Drosophila embryos are patterned by signaling through ERK, which is genetically deregulated in multiple human diseases. Quantitative studies of terminal patterning have been recently used to investigate gain-of-function variants of human MEK1, encoding the MEK kinase that directly activates ERK by dual phosphorylation. Unexpectedly, several mutations reduced ERK activation by extracellular...

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Identifiers

PMID: 33476180
DOI: 10.1091/mbc.E20-10-0625
PMCID: PMC8108529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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