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Article

LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels.

Scientific reports - 2 Dec 2019

Leinonen Jaakko T, Chen Yu-Chia, Pennonen Jana, Lehtonen Leevi, Junna Nella, Tukiainen Taru, Panula Pertti, Widén Elisabeth

Abstract excerpt

Genome-wide association studies (GWAS) have recurrently associated sequence variation nearby LIN28B with pubertal timing, growth and disease. However, the biology linking LIN28B with these traits is still poorly understood. With our study, we sought to elucidate the mechanisms behind the LIN28B associations, with a special focus on studying LIN28B function at the hypothalamic-pituitary (HP) axis that is...

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Identifiers

PMID: 31792362
DOI: 10.1038/s41598-019-54475-6
PMCID: PMC6889388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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