Article
Transient modification of lin28b expression - Permanent effects on zebrafish growth.
Molecular and cellular endocrinology - 5 Jan 2019
Leinonen Jaakko T, Chen Yu-Chia, Tukiainen Taru, Panula Pertti, Widén Elisabeth
Abstract excerpt
Recent genome-wide association studies and mouse models have identified LIN28B as a gene affecting several pubertal timing-related traits and vertebrate growth. However, the exact biological mechanisms underlying the associations remain unknown. We have explored the mechanisms linking LIN28B with growth regulation by combining human gene expression data with functional models. Specifically, we show that 1)...
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