Article
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Human molecular genetics - 1 Jul 2013
Cousminer Diana L, Berry Diane J, Timpson Nicholas J, Ang Wei, Thiering Elisabeth, Byrne Enda M, Taal H Rob, Huikari Ville, Bradfield Jonathan P, Kerkhof Marjan, Groen-Blokhuis Maria M, Kreiner-Møller Eskil, Marinelli Marcella, Holst Claus, Leinonen Jaakko T, Perry John R B, Surakka Ida, Pietiläinen Olli, Kettunen Johannes, Anttila Verneri, Kaakinen Marika, Sovio Ulla, Pouta Anneli, Das Shikta, Lagou Vasiliki, Power Chris, Prokopenko Inga, Evans David M, Kemp John P, St Pourcain Beate, Ring Susan, Palotie Aarno, Kajantie Eero, Osmond Clive, Lehtimäki Terho, Viikari Jorma S, Kähönen Mika, Warrington Nicole M, Lye Stephen J, Palmer Lyle J, Tiesler Carla M T, Flexeder Claudia, Montgomery Grant W, Medland Sarah E, Hofman Albert, Hakonarson Hakon, Guxens Mònica, Bartels Meike, Salomaa Veikko, Murabito Joanne M, Kaprio Jaakko, Sørensen Thorkild I A, Ballester Ferran, Bisgaard Hans, Boomsma Dorret I, Koppelman Gerard H, Grant Struan F A, Jaddoe Vincent W V, Martin Nicholas G, Heinrich Joachim, Pennell Craig E, Raitakari Olli T, Eriksson Johan G, Smith George Davey, Hyppönen Elina, Järvelin Marjo-Riitta, McCarthy Mark I, Ripatti Samuli, Widén Elisabeth
Abstract excerpt
The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically...
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