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Article

Genetic Relationship Between Menarche and Height in East Asians: Functional Role of LIN28B in Pubertal Timing and Growth.

The journal of gene medicine - 1 Nov 2025

Lin Ying-Ju, Li Ju-Pi, Chen Hou-Ren, Lin Ming-Kuem, Chang Cherry Yin-Yi, Lu Hsing-Fang, Liang Wen-Miin, Chiou Jian-Shiun, Yang Jai-Sing, Chou Chen-Hsing, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Chou I-Ching, Li Te-Mao, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Observational and genetic studies associate later menarche with greater height, but their causal relationship, shared genomic regions, and LIN28B's role in puberty and growth remain unclear. METHODS: We conducted genetic correlation, bidirectional Mendelian randomization (MR), and local genetic correlation analyses between menarche timing and adult height in 309,507 East Asians from Taiwan Biobank...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41276933
DOI: 10.1002/jgm.70052

Genes

LIN28B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Genetic Relationship Between Menarche and Height in East Asians: Functional Role of LIN28B in Pubertal Timing and Growth.PMID 41276933Read ↗

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